For patients such as those treated on RTOG with primary chemoradiation, detailed nomograms have been derived from that dataset combined with RTOG , enabling prediction of outcome based on a large number of variables. The risk of regional cancer recurrence after neck dissection is often estimated  from a large series based on all upper aerodigestive squamous cell cancers. In this series, the overall risks at three years by pathological stage AJCC 7 were: .
In , squamous cell cancer of the head and neck region was the fifth most common cancer other than skin cancer, globally, with an annual incidence of , cases and about 60, cases annually in the United States and Europe.
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The highest incidence age group was 60—69, and was higher in Caucasians than in other races. This in turn may overestimate the severity of the disease status. There has been a global trend in increasing OPC incidence, particularly in North America and northern Europe, but even in Taiwan, which has a very high rate for all cancers of the head and neck region, OPC rates increased increased more rapidly between and than any other cancer site.
From Wikipedia, the free encyclopedia. Anatomy of oropharynx and surrounding structures. Main article: HPV-associated oropharyngeal cancer awareness and prevention. At five years, locoregional control was improved with chemotherapy but adverse events were greater. Distant metastases were not affected. Low risk is T1-T2 N0-N1 with negative margins. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years". Papillomavirus Research. Journal of Clinical Oncology Review. Lindberg, Robert June Mehanna, H. BMJ Editorial. Nguyen, N.
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